Thymie Lymphomas in Mice with a Truncating Mutation in Brca2l
نویسندگان
چکیده
Inherited mutations in the BRCA2 gene predispose women to breast and ovarian cancer. We created a mutation in the mouse Brca2 gene that terminates translation in exon 11 at 45% of the normal transcript length. Ninety % of Brca2""ICl"n homozygous mutant mice die prenatally or perinatally. The location of the Brca2""'c<"" mutation differs from those reported previously, and this phenotype suggests a correlation with gen otype analogous to that previously reported in humans. Although hét érozygotemice have remained free of tumors for 10 months, Brca2""'Cam homozygous mutants that survived to adulthood died with thymic lymphomas between 12 and 14 weeks of age.
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